Many excellent papers about the ototoxicity of many chemical agents have been published. However it is sometimes difficult to compare their results each other because of the difference of the way of administration. In this paper we showed the effect of the difference of the administration on the ototoxic action using Nitromin and Cisplatin. Intravenous administration is better than intramuscular or intraperitoneal administration to get the constant ototoxic effect. We also presented how to make the intravenous administration via axillary vein of the guinea pigs.
