聴覚誘発電位の発達に対する実験的脱髄の影響

抄録

The time course of maturation of the auditory evoked potentials (AEPs) has been reported. To study the contribution of myelination to this process, we administered phenylalanine and p-chlorophenylalanine to rat pups and compared the maturation of the early, middle and late components of their AEPs to those of their littermates. Reduction in response latency with age was retarded in the treated group, and latency prolongation with high stimulus rates was greater. If stimulated by paired clicks, the treated animals displayed more severe amplitude reduction and greater latency prolongation in their responses to the second click than did their littermates. The treated animals did not, however, differ appreciably in the waveforms of the responses, age of onset of the responses, or in response thresholds. It appears that observation of the effects of high stimulus rates or short interstimulus intervals may contribute to the assessment of demyelinaing disorders.