実験動物における耳硬化症

抄録

Cochlear emulsion of outbred guinea pig (Hartley) is injected in the legs of inbred guinea pig (No2. N. I. H.)
After several months of repeated injection, hearing test of electrocochleargram and histrogical examination show complete hearing loss and strong ossification around the cochlear. In a most advanced case, new bone invate deep in the endochondral layer of the cochlear bone and destroy the inner ear.
Compare the high probability of ossification in the cochlear on the immunized animal with the non ossification on the controled nonimmunized one, ossification should be occured by the immunological method.