幼若モルモットにおけるFurosemideのEP低下作用とそれに対するGlycerol効果について

抄録

Furosemide, as a loop diuretic, induce a transient decrease of the endocochlear potential (EP) in guinea pig. In case of adult guinea pig, glycerol opens blood cochlear barrier and facilitates furosemide to reach its site of action in stria vascularis (Ohmura et al., 1981). From the developmental view of barrier in this experiment, EP of guinea pig neonate was continuously measured in two groups. In both groups 10-30mg/kg of furosemide was administered; in one group glycerol was administered 15 minutes prior to the injection of furosemide. The EP decrease by furosemide in neonate showed significantly higher than that in adult and was not potentiated even in glycerol pretreated group. These two results, higher EP decrease in neonate and no potentiation by glycerol, indicate that neonate has still immature function of the blood cochlear barrier.