内耳液イオン組成に対する実験的急性高血圧の影響
1982 年 13 巻 1 号 p. 52-54
詳細
1982 年 13 巻 1 号 p. 52-54
With intraperitoneal injection of 0.16 mg/Kg Methoxamine Hydrochloride, experimental acute hypertension was made on the guinea pig. Blood pressure was measured with the physiological pressure tranceducer. The initial mean blood pressure was 50-60 mmHg and Methoxamine caused a rapid increase of 50-60 mmHg.
When the blood pressure reached to the maximum pressure, guinea pig was sacrificed to collect the perilymph with the small glass capillary. Sodium and Potassium concentrations of the perilymph were determined with FML3 Flame Photometer.
The results were these;
Perilymph of the Scala tympani---Na+; 133.4±1.9mEq/L, K+; 14.5±0.9 mEq/L
Scala vestibuli-Na+; 124.0±3.6mEgiL, K+; 20.1±0.7mEq/L
Compared with the normal values of ions in the perilymphs, acute hypertension caused the increase of Potassium and decrease of Sodium. This results suggest the change of permiability of the Blood-Perilymph Barrier and these pathological change of the Blood-Perilymph Barrier may cause the disturbance of Homeostasis of the inner ear.
