内耳の免疫学的研究

抄録

This study was done for the purpose to clarify the inner ear immune system. Previously we proposed that the perilymphatic inner ear immune system is independent of that of the cerebrospinal fluid. In the present study, the effect of dilatation of blood vessels surrounding the cochlea of chinchillas on the transfer of serum antibodies to the perilymph was tested. The possibility of local antibody production in the perilymphatic space was also investigated. The antigen was introduced into the inner ear through the facial nerve canal. The dilatation of blood vessels accerelated the transfer of serum antibodies to the perilymph, even though this activity was limited. The evidence supports our previous proposition. Results of the present study would deny local antibody production in the inner ear, particularly in the perilymphatic space.