中耳ウイルス感染の実験的研究 (第2報)
耳管病変
1986 年 17 巻 1 号 p. 121-123
詳細
1986 年 17 巻 1 号 p. 121-123
In the previous report, we have demonstrated that Sendai virus could induce viral lesion of the middle ear mucosa in guinea pigs. This study further revealed the histopathological aspect of the eustachian tube epithelia in these animals. The filamentous structure was found in some of the epithelial cells which was deemed as viral nucleocapsids based on immunolabeling with HRP. The lumen of the tube was often filled with the effusion of rather high electron density. The epithelial layer was flattened and ciliated cell population was markedly decreased. These features indicated disturbance of the mucociliary transport of the eustachian tube epithelia in acute otitis media induced by the virus.
