抄録
Three monkeys (Macaca irus) were inoculated with mumps virus into unilateral cochleas and their inner ears were examined by immunofluorescent microscopy and transmission electron microscopy. The temporal bones were removed after survival period of 14 days when serological tests disclosed elevation of the titer for antimumps virus antibody. Immunofluorescent microscopy revealed that viral antigen was positive in stria vascularis. When examined by EM, one of two animals were found to have contracted acute labyrinthitis. The pathological changes were especially marked in the organ of Corti and stria vascularis: The inner and outer hair cells were mostly lost or degenerated throughout the cochlea. In the stria, both marginal and intermediate cells were affected. It was possible to see some of marginal cells shedding mature viruses into the endolymph. These pathological changes were similar to those previously observed in guinea pigs and thus were considered as specific features of mumps virus infection of the cochlea.
