実験的鼓膜穿孔の治癒過程における上皮成長因子 (EGF), トランスフォーミング成長因子β (TGF-β) の影響
1989 年 20 巻 1 号 p. 131-132
詳細
1989 年 20 巻 1 号 p. 131-132
The effects of EGF (Epidermal Growth Factor) and IGF-β (Transforming Growth Factor-β) on the healing process of tympanic membrane perforations were studied in guinea pigs. Electrical burn perforations with the same form and size were made in the posterosuperior quadrants of ear drums. The subjects consisted of three groups; the first group with EGF applied daily topically; the second with TGF-β in the same way used and the third with spontaneous healing. The first group showed the shortest duration for closing perforation with more rapid and more thickened proliferation of the squamous epithelium than the third group. The second group tends to have spent longer time for closing perforations than the third group.
