We tried to make active endolymphatic hydrops in guinea pigs by four kinds of stress-stimulations. And with intravenous injection of the enzyme, horseradish peroxidase (HRP), it was revealed that the stria vascularis vessels in experimental guinea pigs were more permeable than those in sham operative ones. On the increased permeability of HRP in stria vascularis vessels in our experiment, the mechanisms were proved to be due to both its leakage through loosed tight junctions and an increased amount of its transportation by pinocytotic vesicles.