イソソルヒド投与による内リンパ水腫面積変化の計測

抄録

Isosorbide was administered to guinea pigs with experimentally induced endolymphatic hydrops. Following this, the area of endolymphatic space cross sections and the length of Reissner's membrane were measured using a microscope, video camera, and computer arrangement. The results were then compared with those for guinea pigs which had not received isosorbide. Decrease in endolymphatic hydrops were most pronounced in the saccule and the basal turn of the cochlea, where reduction rates of 25-30% occurred. Decrease became progressively smaller in the cochlea as it progressed toward the apex. The utricular space was virtually unaffected. Reissner's membrane, elongated by expansion of the endolymphatic space, showed no contraction following isosorbide administration, though significant folding was observed.