エンドトキシンの耳管排泄機能に対する影響

抄録

The clearance of ³H-Salmonella endotoxin inoculated into the middle ear and its fate were studied and the following results were obtained. 1. Neutophils (6-24h) and then macrophages (48-120h) migrated into the middle ear but these cells contained few endotoxin grains. 2. The radioactivity of the endotoxin decreased quickly in the middle ear untill 6 hours but reappeared partially 12-24 hours after inoculation. Most of them was cleared 48 hours after inoculation. 3. The histological changes of noncliated mucosa was observed whereas no significant change in ciliated mucosa. These results suggest that free endotoxin may cause severe damage of the middle ear mucosa when tubal function is impaired.