A 0.2ml of histamine was injected into the bulla of the guinea pigs, and the mucociliary pathology was examined at 1, 3, or 8 days postinjection. 2.7×10-6M of histamine produced temporary middle ear effusions (MEE), and that of 2.7×10-4M did prolonged MEE. 2.7×10-6M-histamine induced mucociliary dysfunction, but the function in the tube and the proximal mucosa recovered at 8 days. The functional recovery in any location was not fully demonstrated even at 8 days when 2.7×10-4M-histamine was injected. In conclusion, histamine could be involved in otitis media with effusion through its effect on the mucociliary system.
