ゴールデンハムスターにおけるCDDP聴器毒性に対する次硝酸ビスマスの効果
1989 年 20 巻 1 号 p. 63-64
詳細
1989 年 20 巻 1 号 p. 63-64
The Present study was designed to examine the effect of bismuth subnitrate (BSN) on the ototoxicity of cis-diammine dichloroplatinum (CDDP), using normal golden hamster. BSN was poured into the stomach during five days. On the 6th day, CDDP was injected intraperitoneally at 10mg/kg or l2mg/kg for once. After observation with scanning electron microscope, the remaining of outer hair cells were counted from apical turn to basal turn, and cytocochleograms were made. In the investigation of the cytocochleograms, the rate of hair cells remaining was slightly higher in the BSN-given groups than in the BSN-ungiven groups, at the distance of 3-4mm from apex. This result was considered to show the protective effect of BSN against nephrotoxicity, although the relationship between the cochlea and the effect of BSN was unknown.
