モルモットにおける白金制癌剤4種の聴器毒性比較

抄録

Four kinds of anticancer platinum drugs (Cisplatin, Carboplatin, 254-S and DWA2114R) were administrated to the guinea pigs intraperitoneally. Ototoxicities of these four drugs were investigated electrophysiologically and morphologically. The group of Cisplatin was divided into three groups of 5mg/kg for 3 consecutive days, 5mg/kg for 2 consecutive days and 1mg/kg for 5 consecutive days. The ratio of doses per each administration of these drugs was 1 (Cisplatin) to 3 (254-S) to 10 (Carboplatin and DWA2114R), which are based on LD₅₀. From the result of N₁, threshold of action potential, ototoxicity of DWA2114R was milder than the other three drugs. And from the survived outer hair cell numbers (%) counted by scanning electron microscopy, ototoxicities of Cisplatin and 254-S were stronger than those of Carboplatin and DWA2114R.