カナマイシン難聴モルモットの蝸牛神経自発放電頻度に及ぼすキシロカインの影響
1989 年 20 巻 1 号 p. 77-78
詳細
1989 年 20 巻 1 号 p. 77-78
Our previous reports showed that the cochlear spontaneous discharge rate was decreased following the injection of 5mg/kg of lidocaine to the aspirine-treated guinea pigs. This study is aimed to know whether or not changes of cochlear spontaneous discharge rate occur after the the cochlea is impaired by injection of kanamycin.
Guinea pigs were treated with intramuscular injections of kanamycin at a dose of 400mg/kg for 8 or 12 consecutive days, until the hearing loss appeared.
The cochlear spontaneous dischage rate was decreased significantly (p<0.05) following the injection of 5mg/kg lidocaine. Thethreshold to the tone stimuli was not changed.
It is suggested that the tinnitus originated from abnormal cochlear spontaneous discharges may be relieved by the injection of lidocaine.
