1990 年 21 巻 1 号 p. 151-152
Dengue virus was injected into the facial canal of the guinea pig from the stylomastoid foramen. It had been proved that the injected materials reach the inner ear via the cochlear and vestibular nerves.
Animals were sacrificed 4 weeks after the injection. Temporal bones were examined light microscopically. Prominent findings were;
1) Edematous swelling of the mucoperiosteum of the middle ear.
2) Marked swelling and slight degeneration of the facial nerve.
3) Partial degeneration of cochlear neurons in tne osseous spiral lamina.