In the secondary endolymphatic sac (e. sac) immune responses against KLH, the characterization of Na+ and K+levels in perilymph over 6 days was investigated in Hartley guinea pigs. No significant difference of Na+and K+level was seen between the KLH challenged ears (right) and the KLH unchallenged ears (left). At day 2-3, a marked cellular infiltration within the e. sac was seen. Endolymphatic hydrops started from 1st day and rapidly increased to maximum on 2nd day. These results stiggested that the inner ear dysfunction might be mainly caused by direct damage through some agents of inflammatory mediator and acute formation of the endolymphatic hydrops rather than change of Na+and K+level in perilymph.
