内リンパ嚢局所免疫反応における内耳機能障害の機序
2. 免疫組織学的検討
1990 年 21 巻 1 号 p. 159-160
詳細
1990 年 21 巻 1 号 p. 159-160
To investigate the distribution of IgG and C3 complement in the inner ear over a 4week period as a result of a secondary endolymphatic sac (ES) immune response against keyhole lympet hemocyanin (KLH), immunohistochemical methods were used. Guinea pigs were employed and antibodies against KLH, guinea pig IgG and C3 complement were used. At days 2-3, moderate endolymphatic hydrops were observed within the inner ear with a massive cell infiltration within the ES and then gradually decreased in the degree (Fig. 1). Diffuse IgG and C3 stainings were localized within the ES, the epithelial and subepithelial region of the vestibule, as well as the spiral ligament and the hair cells in the almost same manner after antigen challenge. IgG bearing cells were detected only within the perisaccular region.
