メニエール病の治療におけるEBM

抄録

For the treatment of patients with Meniere's disease in the acute period, randomized controlled trials showed that anti-vertigo drugs, such as diphenidol and betahistine, are significantly effective. In the chronic period, Meniere's disease is specifically managed by osmotic diuretic, isosorbide. The dose comparative study showed that its opitimal dose is 90ml/day. Despite many controversies against endolymphatic sac surgery, including the Danish sham surgery study suggesting a placebo effect of mastoidectomy, the efficacy of the procedure is widely accepted. However, it is not clear that endolymphatic sac surgery alters the natural history of Meniere's disease in a long term.