Lately, it is reported that sudden deafness and the deafness followed by cisplatine treatment might be related to free radicals. However, the distribution of SOD (superoxide dismutase) in the rat inner ear is not elucidated. In this study the distribution of MnSOD (manganese superoxide dismutase) in the rat cochlea was revealed by immunohistochemical stain. The distribution pattern might suggest that the rich vascular areas were positively stained and MnSOD can be used as an induceble enzyme.
