抄録
Sonolytic hydrolysis of peptides in aqueous solutions and its characteristics have been reported. The sonolysis of an aqueous solution of peptides with added o-dihydroxybenzene brought about hydrolytic products reflecting the amino acid sequence of the peptide, while sonolysis without any additives resulted in oxidation analytes and degradation products originated from side reactions. Although the use of additives such as phenol, m-dihydroxybenzene and p-dihydroxybenzene was also effective in producing sequence related products, several degradation products were produced by side reactions. A remarkable characteristic of the sonolysis of peptides is that the N-terminal side of praline (Xxx-Pro) is more susceptible than other amino acid residues. This characteristic of the sonolysis is superior to that of acid hydrolysis in which cleavage at the C-terminal side of proline (Pro-Xxx) is difficult, and where dehydration products result due to side reactions.
