抄録
The use of high ionic strength (5X) has been proposed to accelerate the well-established biomimetic coating process based on simulated body fluids (SBF). Although the material structure of 5X-SBF apatites has been characterized in several papers, surprisingly little is known about the corresponding biological activities. Since biomimetic apatite formation involve phase transformation of mostly amorphous spherical structures to highly crystalline, plate-like apatite structures, we hypothesize, and found, differential osteoblastic response to each stage of apatite formation as measured by cell viability, cell proliferation, gene expression, and osteoblastic function in vitro. More importantly, possible molecular mechanisms which may be responsible for the observed cell behavior are proposed, in order to provide the fundamental basis toward a better understanding of the material/structure/property/performance paradigm for these interesting biomaterials.
