抄録
A bone substitute made of the native bone components (hydroxyapatite and type I collagen) is expected to have similar properties of bone. Type I collagen is being used in some biomaterials. The finely tuned properties of biominerals over the size, shape and the organization of the constituent crystals is highly controlled by the organic macromolecules present in the serum such as albumin. Earlier we studied the bone-like apatite formation on collagen fibrils by biomimetic method. In the present study the influence of albumin (co-precipitated and pre adsorbed) on the biomimetic crystallization of apatite on Type I collagen fibrils has been studied. Both Co-precipitated and pre adsorbed albumin has shown its strong influence on the micostructure of the crystallized apatite. The crystallinity was found to decrease with an increase in concentration. FT-IR study has confirmed the formation of B-type carbonate bone-like apatite and the presence of BSA in the precipitates.
