We present a case wherein an enterocutaneous fistula was endoscopically closed using an OTSC. A man in his 70s underwent an emergent colostomy and a subsequent sigmoidectomy for sigmoid colon cancer management. After two-stage surgery, an enterocutaneous fistula was identified between the descending colon and the abdominal surgical wound. Endoscopic examination revealed granulation tissue on the oral side of fistula. The granulation tissue was removed with a snare, and the fistula was closed using the OTSC system. Exudates decreased postoperatively and the patient was discharged without complications. This finding indicates that endoscopic closures using OTSC systems can be performed to close enterocutaneous fistulas.
