A 90-year-old man with aortic stenosis was admitted to our hospital for anticoagulation and rate control of new atrial fibrillation. He started to administrate edoxaban. He was consulted to our department for a thorough examination because of continued anorexia. An esophagogastroduodenoscopy revealed esophagitis with easily exfoliated white lichen deposits in the lower esophagus. The histopathological assessment of the lesion showed consistent findings of exfoliative esophagitis, suggesting drug-induced esophagitis. After edoxaban was switched to rivaroxaban as anticoagulant, anorexia improved without any other symptoms.
