A case of multiple granular cell tumors of the colon is reported. A 48-year-old man visited to our hospital because of positive of fecal occult blood reaction. Colonoscopy revealed yellowish-white and hard 12 submucosal tumor (SMT) s, a 5-mm SMT in the cecum and 5-mm to 12-mm SMTs in the ascending colon closed to the hepatic flexure to the splenic flexure of the transverse colon. A few SMTs of the transverse colon was performed by biopsy. HE stainng showed acidophilic granules in the cytoplasm. Granules of cytoplasma were strongly positive with imunostaing for S-100 protein. The diagnosis of granular cell tumor was made. Two SMTs of the transverse colon was removed by endoscopic resection. In Japan, 55 cases including our case were reported for granular cell tumor of the colon, and this was the eighth case report of multiple granular cell tumors of the colon.
