Abstract
Gastroduodenal disease, Helicobacter pylori (H. pylori) infection and gastric mucosa in two Vietnamese areas, Ho Chi Minh and Hue, were studied and compared with Japanese. We used 516 cases in Ho Chi Minh, 108 cases in Hue and 2,104 cases in Japan diagnosed by the same criteria in this study. Age and gender were matched between Ho Chi Minh and Hue cases to compare the difference of gasrtoduodenal disease. It was also matched between Hue and Japan cases with the same method. Age, gender and endoscopic diagnosis were matched in the study of the prevalence of H. pylori infection and gastric mucosa between two areas, Ho Chi Minh and Hue, Hue and Japan.
1) There was no difference in the frequency of gastric cancer and peptic ulcer disease between Ho Chi Minh and Hue. Duodenal ulcer was predominant in Hue (91.3%) and gastric ulcer was predominant in Japan (58.3%) in peptic ulcer disease (P＜0.05) .
2) We found no difference in the prevalence of H. pylori infection between Ho Chi Minh and Hue (48.7%, 58.9%, respectively) . The prevalence of Hue was similar to Japan (50.6%, 45.9%, respectively) .
3) Glandular atrophy and intestinal metaplasia score in H. pylori positive Vietnamese on the lesser curvature of the lower corpus according to the Updated Sydney system, taken in accordance with triple site gastric biopsy method, were low. On the other hand, they were significantly higher in Japanese than in Vietnamese. It was revealed that atrophic change and intestinal metaplasia by H. pylori infection were particular to Japanese.
