Duodenal follicular lymphoma (dFL) is a rare disease, accounting for only 1% to 3% of gastrointestinal non-Hodgkin’s lymphoma. Neither standard surveillance nor treatment for dFL has been established. In this article, we report a case of dFL successfully detected by capsule endoscopy, and followed with a watch-and-wait strategy.
A 59-year-old asymptomatic male was admitted to our hospital for evaluation of confluent whitish granules in the second portion of duodenum detected on screening esophagogastroduodenoscopy. Biopsy specimens showed a nodular lymphocyte expansion, constituted by small cleaved lymphoid cells that were positive for CD20, CD79a, CD10 and BCL2, but negative for CD5 and Cyclin D1. Capsule endoscopy detected the tumors in the second and third portion of duodenum. The final diagnosis was stage I follicular lymphoma, grade 1, of the duodenum. As the lymphoma caused no symptoms, no treatment was performed in accordance of the watch-and-wait policy.
