A 60-year-old woman was admitted to our hospital with abdominal and back pain. CT revealed a low density mass in the pancreas. According to image and EUS-FNA histological findings, we diagnosed her condition as pancreatic neuroendocrine cell carcinoma (NEC) . Subsequently, she underwent systemic chemotherapy (CDDP+CPT-11) . After 4 cycles, the lesion reduced in size remarkably and she underwent surgery. However, brain metastasis appeared after surgery and rapidly progressed leading to the patient’s death. Chemotherapy based on the treatment for small cell lung cancer is also recommended for pancreatic NEC. However, there is no recommended chemotherapy schedule and no consensus for the strategy for brain metastasis in pancreatic NEC. Evidence showing pancreatic NEC is necessary, including a schedule for chemotherapy and a strategy for brain metastasis.
