A 73-year-old man with a history of sigmoid colon cancer was diagnosed as having advanced gastric cancer at the esophagocardiac junction with multiple liver metastasis. The biopsy revealed poorly differentiated adenocarcinoma which was HER-2 negative. Six cycles of chemotherapy with CDDP/S-1 were administered. Three months after the initial treatment, dendritic cell vaccines pulsed with Wilms tumor 1 peptide antigen were administered in one course which comprised 7 bi-weekly sessions. After four months of treatment the multiple liver metastasis had disappeared on computed tomography imaging. After nine months, gastrointestinal endoscopy revealed that the primary gastric cancer lesion on the esophagocardiac junction had also resolved. Based on the results of these examinations, the response was judged as complete. He remains well with no recurrence of the gastric cancer or and metastatic lesions for more than four years after starting treatment. This combination therapy might play an important role in the treatment of a certain type of patient with gastric cancer and liver metastases.
