Pneumatosis cystoides intestinalis (PCI) is a rare intestinal condition that is characterized by the presence of gaseous cysts within the intestinal wall. We herein report a case of PCI after treatment with mitiglinide/voglibose. A 74-year-old man had diabetes mellitus for 7 years, and was being treated with mitiglinide/voglibose since 5 years and 5 months. Recently, after he complained about constipation, further examination was performed. Colonoscopic examination revealed multiple elevated lesions with smooth surface-like submucosal tumor in the sigmoid colon. Histopathological findings demonstrated fissure-like cavities and granuloma with multinuclear foreign body giant cell. Computed tomography showed multiple cystic lesions in the colonic wall of the sigmoid colon. We diagnosed PCI, and discontinued treatment with mitiglinide/voglibose. Two months later, he was retreated with only mitiglinide. Four months later, colonoscopic examination revealed elimination of elevated lesions.
