The incidence of gastric cancer after eradication of Helicobacter pylori (HP) is expected to increase in the future. Although reports of early gastric cancer after the eradication account for the majority of cases, scirrhous gastric cancer is rare. Herein, we report three cases of scirrhous gastric cancer after eradication of HP. Case 1: A 50-year-old woman had been treated with eradication of HP and was followed up by esophagogastroduodenoscopy (EGD) on a regular basis. Two years after the eradication, EGD revealed advanced type 4 gastric cancer. Case 2: A 50-year-old woman had been treated with eradication and was followed up by EGD on a regular basis. Twenty-four years after the eradication, EGD revealed advanced type 4 gastric cancer. Case 3: A 50-year-old man had been treated with eradication and was followed up every year by EGD. Five years after the eradication, EGD revealed advanced type 4 gastric cancer. Despite performing regular EGD, cases of scirrhous gastric cancer can be found after eradication. We report our encountered cases, along with relevant literature.
