Eosinophilic gastrointestinal diseases (EGIDs) are distinct immunologic diseases that show a variety of clinical manifestations and endoscopic findings with unknown cause or association of immunologic diseases. The incidence of eosinophilic esophagitis (EoE) seems to be increasing, although it is still unclear whether this is general phenomenon or attributable to an increased awareness of the disease. Our aim was to examine clinical features, endoscopic findings, and associated diseases of 4 cases of EGIDs. These cases included 1 eosinophilic gastroenteritis and 4 EoE, 3 men and 1 woman, and the mean age was 46±7 year-old. The most common endoscopic findings were mucosal edema, linear furrows, and rings in esophagus, and white specks in colon. An increased number of eosinophils was infiltrated in esophageal or colonic epithelium. Two cases were complicated with celiac disease (CD), and scleroderma, respectively and all cases were associated with gastroesophageal reflux disease. While one case complicated with CD showed a marked serum eosinophilia, others were in normal serum eosinophils. Three cases were treated with a proton-pump inhibitor and the symptoms improved in 2 cases.
