A 72-year-old man was admitted to our hospital because of gastric mucosal irregularity on gastroscopic examination. He was successfully treated for Helicobacter pylori infection at the age of 63 years. Blood examinations, including tumor markers, revealed normal results. Upper gastrointestinal endoscopy revealed a large 0-IIc lesion measuring 10 mm in the gastric body. The biopsy revealed atypical glands. Enhanced computed tomography revealed no metastasis to the lymph nodes or other organs. Therefore, a diagnosis of early gastric cancer was made and endoscopic submucosal dissection (ESD) was performed. The biopsy specimen revealed gastric carcinoma with lymphoid stroma on hematoxylin and eosin staining, Epstein-Barr encoding region in situ hybridization revealed that tumor cells were positive for Epstein-Barr virus (EVB). Hence, the patient was diagnosed with EBV-associated carcinoma with lymphoid stroma.
Here, we have reported a case of EBV-associated carcinoma with lymphoid stroma that was diagnosed using ESD.
