Relation between Taurocholic Acid and Atrophic Gastritis

Abstract

Relation between refluxed taurocholic acid into the stomach and atrophic gastritis, endoscopic forms of the pylorus were studied.
1) A frequency of refluxed cases of taurocholic acid in the stomach occupied 41.0% out of 39 cases.
2) We used Oshima's criteria in order to observe the relation between taurocholic acid and gastric mucosa. Gastric mucosa was classified into 3 groups, which were (+) and (±) group, (+) group and (⧺) group. Refluxed frequency and concentration in (+) and (±) group showed low level (each 18.8%, 1.82nmol/ml) . On the other hand, these levels were high in (+) group which has atrophic change and (⧺) group which has remarkable atrophic change ( (+) group : 57.1%, 17.43nmol/ml, (⧺) group : 55.6%, 21.45nmol/ml) . We considered the effect of taurocholic acid to atrophic change in gastric mucosa.
3) We couldn't find difference between taurocholic acid and form of pyloric ring, peristalsis.