Abstract
A 48-year-old female patient visited to Chiba Cancer Center to receive a thorough examination of the transverse colon polyp. Barium enema examination revealed a smooth surfaced submucosal tumor sized 10mm in the transverse colon closed to the lienal flexure. Colonoscopic examination showed a sessile, slightly yellowish submucosal tumor. A biopsy of the tumor was performed and the tumor was histologically confirmed as granular cell tumor, and endoscopic polypectomy was applied. The resected specimen was solid and sized 10×8×6mm.
The tumor was mainly situated in the submucosal layer and demarcated well. Histologically, the tumor cell was relatively large, and each cell had eosinophilic granules in the cytoplasm. An immunohistochemical analysis revealed positivity for S-100 protein and neuron specific enolase (NSE) . So the diagnosis of granular cell tumor of the colon was made.
Granular cell tumor of the large bowel in Japan were reported 21 cases inclusive of our case. We discussed the characteristics of our case comparing them.
