Proton pump inhibitorが著効した胃全摘術後逆流性食道炎の2例

抄録

It has been reported that one of the effects of proton pump inhibitor (PPI) is inhibition from exocrine pancreas. We treated two cases of reflex esophagitis due to total gastrectomy with PPI and they were cured soon.
Case 1 : A 71-year-old man was operated upon total gastrectomy (6-interposition) for early gastric cancer. He had felt aphagia and heart burn from ten days after operation. We had been following up him for three years with camostat mesilate, but his symptoms had been unchanged and the endoscopy had revealed esophagitis which was Savary-Miller (SM) stage III.
Case 2 : Total gastrectomy (Roux-Y) for early gastric cancer was carried out to a woman who was 53 years old. Her symptoms were nausea and heart burn from eight days after operation. She had never been treating by any medicines. Four months after operation, her symptoms had been stronger and endoscopic findings was esophagitis of SM stage III.
In both cases, their symptoms were got under control soon and esophagitises were changed to SM stage I-II with single medication of PPI for several weeks.