歯周疾患とβ-Glucuronidase との関係についての研究

II. 歯肉浸出液中のβ-Glucuronidase 活性値

抄録

β-Glucuronidase activities in gingival fluid from patients with periodontal disease were measured by a modified Fishman's method (Kaizu's method), and compared with various clinical findings such as PMA-index by Schour and Massler, DI-score and CI-score by Green and Vermillion, pocket depth (mm) by a pocket marker, alveolar bone loss (%) by Schei et al., quantity (mg) of gingival fluid and salivary pH.
The following results were obtained:
1. The β-glucuronidase activities in gingival fluid were able to demonstrate and measure in all subjects.
2. Statistically significant correlations were shown between β-glucuronidase activities and the following clinical findings; PMA-index (P<0.05), DI-score (P<0.01), CI-score (P<0.05), pocket depth (P<0.001), alveolar bone loss (P<0.001) and quantity of gingival fluid (P<0.01), except salivary pH.
3. The β-glucuronidase activities of periodontal disease groups were remarkably higher than that of clinical healthy group (P<0.01), and had a tendency to increase according to the progression and aggravation of the disease.
It is concluded from these results that the β-glucuronidase activity in gingival fluid is closely related to each clinical finding and process of periodontal disease.