抄録
The effects of fluoride on the enzyme activities of the periodontal tissues of rats, that received either 50ppm NaF or 100ppm NaF in the drinking water for a year, were investigated histochemically. The activities of the enzymes studied were alkaline phosphatase, acid phosphatase and β-glucuronidase.
1. Alkaline phosphatase activity decreased in the periodontal tissues of both NaF 50ppm and NaF 100ppm groups, as compared with that of the control group. There was little difference in acid phosphatase activity among the periodontal tissues of the three groups (the control, NaF 50ppm and NaF 100ppm groups). The activity of β-glucuronidase almost disappered in the periodontal tissues of both NaF 50ppm and 100 NaF ppm groups, whereas the marked activity of the same enzyme was recognized in the periodontal tissues of the control group.
2. Alkaline phosphatase activity decreased in the bone of the body of the maxilla of both NaF 50ppm and NaF 100ppm groups, as compared with that of the control group. Acid phosphatase activity in the bone of the body of the maxilla was almost the same in both control and NaF 50ppm groups, but the activity decreased in the similar area of NaF 100ppm group.
