Journal of Photopolymer Science and Technology
Online ISSN : 1349-6336
Print ISSN : 0914-9244
pH-Sensitive Polymeric Micelles for Enhanced Intracellular Anti-cancer Drug Delivery
Masao KamimuraYukio Nagasaki
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2013 Volume 26 Issue 2 Pages 161-164

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Abstract

Polyion complex (PIC) micelles are expected to be used as nanocarrier for drug delivery. The PIC micelles formed by cationic anti-cancer drug, doxorubicin (DOX) and poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) (PEG-b-PVBP) (DOX@PNP) was prepared with different pH conditions and composition ratio of the mixture. DOX and PEG-b-PVBP were spontaneously self-assembled in aqueous solutions into nanoparticles with average size of 45-55 nm over the entire range of the compositions of the mixtures including stoichiometric electroneutral complexes. The DOX@PNP described here would be promising nanocarrier for anti-cancer drug delivery.

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© 2013 The Society of Photopolymer Science and Technology (SPST)
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