Surface modification on rare-earth doped ceramic nanophosphors via ligand exchange method for near-infrared biophotonics

Masao Kamimura; Satoru Suyari; Taiki Matsumoto; Kohei Soga

doi:10.2494/photopolymer.28.711

Masao Kamimura, Satoru Suyari, Taiki Matsumoto, Kohei Soga

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Keywords: bioimaging, near-infrared, second biological window, poly(ethylene glycol), ligand exchange

JOURNAL FREE ACCESS

2015 Volume 28 Issue 5 Pages 711-713

DOI https://doi.org/10.2494/photopolymer.28.711

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Abstract

The surface of NaYF₄ NPs were successfully modified via stepwise modification procedure, ligand exchange and electrostatic adsorption reactions. The obtained PEGylated NaYF₄ NPs showed high dispersion stability under physiological conditions. Furthermore, the PEGylated NaYF₄ NPs displayed minimal cell cytotoxicity in the range of general criteria of RED-CNPs concentration for live cell imaging. Therefore, the obtained PEGylated NaYF₄ NPs is a promising candidate of NIR imaging probes.

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