Fluorescent Polystyrene Latex Nanoparticles for NIR-II in vivo Imaging

Masao Kamimura; Yuichi Ueya; Eiji Takamoto; Kazuhiro Iso; Moe Yoshida; Masakazu Umezawa; Kohei Soga

doi:10.2494/photopolymer.32.93

Fluorescent Polystyrene Latex Nanoparticles for NIR-II in vivo Imaging

Masao Kamimura, Yuichi Ueya, Eiji Takamoto, Kazuhiro Iso, Moe Yoshida, Masakazu Umezawa, Kohei Soga

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Keywords: Second biological window, NIR-II, Fluorescence in vivo imaging, Fluorescent beads, Latex nanoparticles

JOURNAL FREE ACCESS

2019 Volume 32 Issue 1 Pages 93-96

DOI https://doi.org/10.2494/photopolymer.32.93

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Abstract

In this study, tissue-penetrable near infrared (NIR)-II fluorescent polystyrene latex nanoparticles (NIR-PSt NPs) were designed and prepared as deep tissue in vivo imaging probes. An NIR-II fluorescent dye was successfully loaded into PSt NPs. The resulting NIR-PSt NPs showed strong NIR-II (1100 nm) emission in an aqueous environment. In addition, in vivo imaging of live mice was successfully performed using these NIR-PSt NPs. The prepared NIR-PSt NPs exhibited remarkable properties for in vivo fluorescence imaging.

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