Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
ISSN-L : 0386-2208
Review
Pathogen recognition by innate immunity and its signaling
Shizuo AKIRA
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2009 Volume 85 Issue 4 Pages 143-156

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Abstract

Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.

(Communicated by Tadamitsu KISHIMOTO, M.J.A.)

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© 2009 The Japan Academy
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