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Proceedings of the Japan Academy, Series B
Vol. 85 (2009) No. 4 P 143-156




Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.

(Communicated by Tadamitsu KISHIMOTO, M.J.A.)

Copyright © 2009 The Japan Academy

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