Abstract
Effects of MPTP and MPP+, potent dopaminergic neurotoxins, on the activity of NADH-ubiquinone oxidoreductase were studied using isolated mitochondrial preparation from C57BL/6J mouse brains. Both MPTP and MPP+ dose-dependently inhibited activity of NADH-ubiquinone oxidoreductase, however, MPTP found to be a more potent inhibitor compared with MPP+. Significance of these findings was discussed with regard to the mechanism of MPTP-induced neuronal degeneration.
