Toxic effects of glufosinate ammonium (GLA), a non-selective herbicide, on the brain of infantile rats was studied. Because of the structural analogy between GLA and glutamate, GLA-exposed rats were examined for the wet-dog shakes response to kainic acid. Seven-day-old female rats were injected subcutaneously with a dose 1, 2 or 5mg/kg GLA daily for 7 days. They were weaned at 3 weeks of age and tested for the response to 9mg/kg kainic acid at 5 or 6 weeks of age. The frequency of wet-dog shakes induced by kainic acid showed a significant decrease in all GLA-exposed rats, though there was no significant difference among three dose groups. A significant decrease in the body weight gain was found in the 5mg/kg GLA group. The results suggest that exposure to GLA, even in low doses, during infantile period in the rat induces alterations in the kainic acid receptor in the brain.
The Japan Academy