Abstract
A eleven-year-old epileptic boy with hyperuricemia was admitted to our hospital complaining of convulsion. The onset of grand mal seizures : initiated in 9 years of age. The EEG record showed repetitive small negative spikes in left temporal lead. In mental examination he was normal and had no abnormal behavior or self mutilation.
On admission the serum uric acid was 10.2 mg/dl (normal 3.5-6.9 mg/dl) and the activities of HGPRT-ase and APRT-ase in red cells were, normal. The serum uric acid leveles with his parents and younger brother, were within normal range, and the activities of HGPRT-ase and APRT-ase were also almost normal. Allopurinol was favorably effective for the hyperuricemia, but did not influence on the EEG.
These data suggested that no correlation might be recognized between neurological symptoms and hyperuricemia in spite of a hypothesis that in Lesch-Nyhan syndrome hyperuricemia is an etiologic factar.
