Abstract
There is a growing concern that some of the drugs may produce genetic damage. Recently, many investigators have been reported that several drugs were added to the list of the chemicals capable of causing abnormalities in the chromosome of human somatic cells.
The present study was undertaken to determine whether N- (3', 4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a very effective anti-allergic agent, induced chromosome abnormalities in cultured human embryonic skin cells. As the results, there was no evidence for the increase of chromosome aberrations at a concentration of 200μg/ml or less. At 400μg/ml or higher, inhibition of cell growth was evident and these concentrations were unsuitable to observation of chromosome aberration in cultured embryonic skin cells.
