A Clinical Study on Urinary Dopamine Excretion in Patients with Chronic Glomerulonephritis Accompanied by Hypertension

Abstract

Urinary free dopamine, urinary kallikrein and urinary sodium excretions were determined before and after furosemide (FM) administration, in 37 patients with chronic glomerulonephritis (CGN) and 11 control subjects. The results were as follows. 1) Urinary free dopamine excretion both before and after FM administration was significantly lower in patients with hypertensive CGN (borderline hypertension and hypertension) than in control subjects. 2) Urinary free dopamine excretion/creatinine clearance (Ccr) was significantly lower in patients with hypertensive CGN than in those with normotensive CGN (before FM administration) and in control subjects (15 minutes after FM administration). 3) Urinary free dopamine and sodium excretions before and after FM. administration were positively correlated in control subjects and in patients with CGN. 4) Urinary free dopamine excretion both before and 15 minutes after FM administration was negatively correlated with mean blood pressure in patients with CGN. 5) Urinary kallikrein excretion both before and after FM administration was not significantly lower in patients with hypertensive CGN than in control subjects. These results suggest a possible role dopamine in the requlation of blood pressure and of renal sodium excretion in patients with CGN.