Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 31, Issue 4
Displaying 1-20 of 20 articles from this issue
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Contents
  • A Clinical Study on Urinary Dopamine Excretion in Patients with Chronic Glomerulonephritis Accompanied by Hypertension
    HIDEMITSU YAMASITA
    1985 Volume 31 Issue 4 Pages 531-539
    Published: December 10, 1985
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.31.531
    JOURNAL FREE ACCESS
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    Urinary free dopamine, urinary kallikrein and urinary sodium excretions were determined before and after furosemide (FM) administration, in 37 patients with chronic glomerulonephritis (CGN) and 11 control subjects. The results were as follows. 1) Urinary free dopamine excretion both before and after FM administration was significantly lower in patients with hypertensive CGN (borderline hypertension and hypertension) than in control subjects. 2) Urinary free dopamine excretion/creatinine clearance (Ccr) was significantly lower in patients with hypertensive CGN than in those with normotensive CGN (before FM administration) and in control subjects (15 minutes after FM administration). 3) Urinary free dopamine and sodium excretions before and after FM. administration were positively correlated in control subjects and in patients with CGN. 4) Urinary free dopamine excretion both before and 15 minutes after FM administration was negatively correlated with mean blood pressure in patients with CGN. 5) Urinary kallikrein excretion both before and after FM administration was not significantly lower in patients with hypertensive CGN than in control subjects. These results suggest a possible role dopamine in the requlation of blood pressure and of renal sodium excretion in patients with CGN.
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  • Bronchial Arterial Injection of Adriamycin and its Anti-tumor Effects
    TOSHINAO KANEMITSU
    1985 Volume 31 Issue 4 Pages 540-552
    Published: December 10, 1985
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.31.540
    JOURNAL FREE ACCESS
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    Forty-eight patients with primary lung cancer (adenocarcinoma ; 24 ; epidermoid carcinoma, 12 ; large-cell carcinoma, 7 ; small-cell carcinoma, 5) were treated with bronchial arterial injection (BAI) of adriamycin (ADR) (30-60mg/body). Serum and tumor tissue concentrations of ADR and the antitumor effects were studied. 1) The half-life of ADR in the serum was 8.5 minutes in the group treated with 30 mg of ADR and 5.8 minutes in that treated with 60 mg of ADR. Thus, ADR disappeared rapidly from the serum. 2) No significant difference in serum concentrations between the group with good response and that with poor response or between the adenocarcinoma group and epidermoid carcinoma group were observed. Seven to 10 days after the BAI, 0.6-3.07μg/g of ADR were found in the tumor tissue in three patients. 3) Thirty-four percent of the 48 patients showed good response on chest x-ray. About 60% of all patients showed improvement on chest x-ray and/ or in subjective symptoms. It was also confirmed that hypervascular type tumors showed good response. No difference in therapeutical effects was observed between the 30 mg group and the 60 mg group. 4) The histological effects were studied in four patients. In three patients, histological improvements were noted, though the degree and distribution of the affected cells varied. 5) As for side effects, the incidence of anorexia and nausea was 25%, while that of depilation and bone marrow disorder was negligible. In conclusion, BAI with 30 mg of ADR produced satisfactory tissue concentrations and good response with the least side effects.
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  • X-ray Study of Small Bowel Inflammatory Disease
    SHIGEO KOBAYASHI
    1985 Volume 31 Issue 4 Pages 553-564
    Published: December 10, 1985
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.31.553
    JOURNAL FREE ACCESS
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    1. Two hundred eighty-four ulcerative lesions found in 45 patients with inflammatory y small bowel disease, which were operated on or dissected in Juntendo University Hospital during the 11 years from January 1973 to December 1983, were studied clinically and pathologically. For the basis of x-ray diagnosis of inflammtory small bowel disease, the shape and distribution pattern of the ulcerations were analyzed. Ulcerations of inflammatory disease are divided by their shape into three groupes, “Point”, “Line” and “Area”. Distribution patterns of the lesions are “Single” and multiplicity, which was classified into “Sporadic”, “Skip”, “Segmental” and “Diffuse”. Characteristic findings were found in each inflammatory disease. In intestinal tuberculosis, annular and girdle ulcerations could often be seen and the distribution pattern was “Single” or “Sporadic”. Typical findings of Crohn's disease were longitudinal and irregular-shaped shallow ulceration with or without cobblestone appearance and multiple ulcerations, such as “Skip” lesions, could be seen at the proximal side of longitudinal ulcer. The lesions so-called “Simple Ulcer” and intestinal Behcet's disease were “Single” or multiple, deep and big ulcerations on or near Bauhin's valve. Usually, ischemic colitis has longitudinal ulcerations could be seen in ischemic enteritis. In amyloidosis and celiac disease in our cases, no ulcerative lesion could be found. 2. The double contrast method of the small bowel by means of duodenal intubation was undertaken 375 times in 337 patients from January 1979 to April 1984 in the gastrointestinal section of our hospital. Estimations of this method were as follows, 1) Good double contrast views of the upper and middle parts of the small bowel could be obtained nearly always in routine examination. In detailed examination, good results could be obtained at every desired part of the small bowel. 2) The double contrast method is best suited for visualizing not only big or medium-sized, but small and fine ulcerations. 3. Inflammatory small bowel diseases should be diagnosed by double contrast pictures within thinking about the shape of ulceration and the distribution pattern.
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